Molecular characterization of neurotransmitter transporters
نویسندگان
چکیده
منابع مشابه
Neurotransmitter Transporters
Neurotransmitters are released into the extracellular space during synaptic transmission. The actions of these chemical signals are terminated through active uptake by transporters that are located in the plasma membrane of neurons and glial cells. Transporters harness electrochemical gradients to force the movement of transmitter back into cells against its concentration gradient. These protei...
متن کاملMolecular mechanism of citalopram and cocaine interactions with neurotransmitter transporters.
The selective serotonin reuptake inhibitors (SSRIs) and cocaine bind to the neural serotonin (5-HT) transporter (SERT) and thus inhibit presynaptic reuptake of 5-HT and elevate its concentration in the synaptic cleft. Cocaine also binds to the dopamine transporter (DAT) and to the noradrenaline transporter (NET) and inhibits presynaptic reuptake of dopamine and noradrenaline. SERT, DAT, and NET...
متن کاملThe molecular logic of sodium-coupled neurotransmitter transporters
Synaptic transmission at chemical synapses requires the removal of neurotransmitter from extracellular spaces. At synapses in the central nervous system, this is accomplished by sodium-coupled transport proteins, integral membrane proteins that thermodynamically couple the uptake of neurotransmitter to the uptake of sodium and, in some cases, the uptake and export of additional ions. Recent X-r...
متن کاملCharacterization of bacterial drug antiporters homologous to mammalian neurotransmitter transporters.
Multidrug transporters are ubiquitous proteins, and, based on amino acid sequence similarities, they have been classified into several families. Here we characterize a cluster of archaeal and bacterial proteins from the major facilitator superfamily (MFS). One member of this family, the vesicular monoamine transporter (VMAT) was previously shown to remove both neurotransmitters and toxic compou...
متن کاملPorters and neurotransmitter transporters.
Uptake of neurotransmitters involves multiple transporters acting in different brain locations under different physiological conditions. The vesicular transporters are driven by a proton-motive force generated by a V-ATPase and their substrates are taken up via proton/substrate exchange. The plasma membrane transporters are driven by an electrochemical gradient of sodium generated by a Na+/K(+)...
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ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 1993
ISSN: 0888-8809
DOI: 10.1210/me.7.12.1517